601 Lexington Avenue is located in the heart of Midtown Manhattan at East 53rd Street and Lexington Avenue, directly across from 599 Lexington Avenue. This 59-story building has direct access to the Atrium Shops and Cafes, home to first class shopping, resturants and a health club.  It also provides the convenience of access to New York City's five boroughs through its prime location atop a major subway station.

601 Lexington Avenue's world-recognized silhouette was designed by Hugh Stubbins & Associates and Emery Roth & Sons. Built in 1977, the retail atrium and open-air concourse were renovated in 1997. A new office lobby was built in 2010. The property is held in a joint venture and Boston Properties' ownership share is 55%.

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